One-pot fabrication of hydrogel coatings that impart anticorrosive, antithrombotic, and superlubricious properties to metallic medical devices is highly desirable, yet remains challenging due to multistep processing, limited multifunctionality, and weak interfacial adhesion. Here, we report an interfacial anchoring-triggered surface photogelation (IASP) strategy for the one-pot construction of multifunctional hydrogel coatings on diverse metallic surfaces. The coating exhibited robust adhesion, achieving a shear strength of 179±43 kPa and an interfacial toughness of 210±32 J m⁻² on magnesium alloy. More importantly, this strategy enables the construction of hydrogel coatings on a broad spectrum of metallic devices, including implantable stents, mechanical heart valves, artificial joint prostheses, and LVAD pumps, thereby providing integrated anticorrosive, antithrombotic, and superlubricious properties for diverse biomedical applications. Notably, the coating maintained its interfacial integrity, with no evident delamination after 3.8 × 10⁸ in vitro fatigue cycles on the stent surface and 5.0 × 10⁶ cycles of in vitro hemi-hip wear testing. In vivo evaluation in a canine coronary artery model further demonstrated that the REDV-incorporated coating promoted favorable re-endothelialization, while also mitigating the corrosion-related limitations of magnesium-based implants, with no detectable thrombosis or in-stent restenosis over 2 years of follow-up.
 

Hydrogel coatings,One-pot fabrication,Metallic substrates,Antithrombotic surfaces,Superlubricity